Lundberg Pontus, Lynd Nathaniel A, Zhang Yuning, Zeng Xianghui, Krogstad Daniel V, Paffen Tim, Malkoch Michael, Nyström Andreas M, Hawker Craig J
Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, Retzius väg 8, Stockholm SE-171 77, Sweden.
Soft Matter. 2013 Jan 7;9(1):82-89. doi: 10.1039/C2SM26996A.
Histamine functionalized poly(allyl glycidyl ether)--poly(ethylene glycol)--poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hudrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.
组胺功能化的聚（烯丙基缩水甘油醚）-聚（乙二醇）-聚（烯丙基缩水甘油醚）（PAGE-PEO-PAGE）三嵌段共聚物代表了一类新型的物理交联、pH响应水凝胶，在生物医学应用方面具有巨大潜力。这些遥爪三嵌段共聚物在pH 7.0以上表现出突然且可逆的水凝胶化，这是由于组胺单元的亲水/疏水转变，形成了由亲水性PEO基质桥接的疏水域网络。随着pH值升高，这些疏水域的有序性得到改善，并在pH 8.0时自组装成体心立方晶格，而在较低浓度下形成明确的胶束。重要的是，在三种不同细胞系上评估时，所有材料均被发现无毒，这表明其具有一系列医学和生物医学应用。
