Gao Yanbing, Zhang Xiaobo, Zhou Haiyu
Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China.
Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou 730030, China.
Pharmaceutics. 2023 Sep 29;15(10):2405. doi: 10.3390/pharmaceutics15102405.
Tissue engineering and regenerative medicine is a highly sought-after field for researchers aiming to compensate and repair defective tissues. However, the design and development of suitable scaffold materials with bioactivity for application in tissue repair and regeneration has been a great challenge. In recent years, biomimetic hydrogels have shown great possibilities for use in tissue engineering, where they can tune mechanical properties and biological properties through functional chemical modifications. Also, biomimetic hydrogels provide three-dimensional (3D) network spatial structures that can imitate normal tissue microenvironments and integrate cells, scaffolds, and bioactive substances for tissue repair and regeneration. Despite the growing interest in various hydrogels for biomedical use in previous decades, there are still many aspects of biomimetic hydrogels that need to be understood for biomedical and clinical trial applications. This review systematically describes the preparation of biomimetic hydrogels and their characteristics, and it details the use of biomimetic hydrogels in bone, cartilage, and nerve tissue repair. In addition, this review outlines the application of biomimetic hydrogels in bone, cartilage, and neural tissues regarding drug delivery. In particular, the advantages and shortcomings of biomimetic hydrogels in biomaterial tissue engineering are highlighted, and future research directions are proposed.
组织工程与再生医学是一个备受研究人员追捧的领域，旨在补偿和修复有缺陷的组织。然而，设计和开发适用于组织修复和再生的具有生物活性的支架材料一直是一项巨大的挑战。近年来，仿生水凝胶在组织工程中显示出了巨大的应用潜力，它们可以通过功能性化学修饰来调节机械性能和生物学性能。此外，仿生水凝胶提供三维（3D）网络空间结构，能够模拟正常组织微环境，并整合细胞、支架和生物活性物质用于组织修复和再生。尽管在过去几十年中人们对各种用于生物医学的水凝胶兴趣日益浓厚，但对于生物医学和临床试验应用而言，仿生水凝胶仍有许多方面需要深入了解。本综述系统地描述了仿生水凝胶的制备及其特性，并详细阐述了仿生水凝胶在骨、软骨和神经组织修复中的应用。此外，本综述概述了仿生水凝胶在骨、软骨和神经组织药物递送方面的应用。特别强调了仿生水凝胶在生物材料组织工程中的优点和缺点，并提出了未来的研究方向。
