多囊卵巢综合征中的二甲双胍临床药理学
Metformin-clinical pharmacology in PCOs.
作者信息
Dumitrescu R, Mehedintu C, Briceag I, Purcărea V L, Hudita D
机构信息
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Gynecology Department, "Dr. I. Cantacuzino Hospital", Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Gynecology Department, "Nicolae Malaxa Hospital", Bucharest, Romania.
出版信息
J Med Life. 2015 Apr-Jun;8(2):187-92.
Oligo-anovulation, hyperandrogenism and insulin resistance characterizes polycystic ovary syndrome (PCOs). Metformin is the oldest insulin sensitizer used in the management of type 2 diabetes mellitus. In PCOs, metformin decreases the serum lipids, androgen and insulin; induces ovulation and regular menstrual cycle; increases the pregnancy rate.
多囊卵巢综合征（PCOS）的特征是少排卵、高雄激素血症和胰岛素抵抗。二甲双胍是用于治疗2型糖尿病的最古老的胰岛素增敏剂。在多囊卵巢综合征中，二甲双胍可降低血脂、雄激素和胰岛素水平；诱导排卵和月经周期规律；提高妊娠率。
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