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多囊卵巢综合征中的二甲双胍临床药理学

Metformin-clinical pharmacology in PCOs.

作者信息

Dumitrescu R, Mehedintu C, Briceag I, Purcărea V L, Hudita D

机构信息

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Gynecology Department, "Dr. I. Cantacuzino Hospital", Bucharest, Romania.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Gynecology Department, "Nicolae Malaxa Hospital", Bucharest, Romania.

出版信息

J Med Life. 2015 Apr-Jun;8(2):187-92.

PMID:25866577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4392089/
Abstract

Oligo-anovulation, hyperandrogenism and insulin resistance characterizes polycystic ovary syndrome (PCOs). Metformin is the oldest insulin sensitizer used in the management of type 2 diabetes mellitus. In PCOs, metformin decreases the serum lipids, androgen and insulin; induces ovulation and regular menstrual cycle; increases the pregnancy rate.

摘要

多囊卵巢综合征（PCOS）的特征是少排卵、高雄激素血症和胰岛素抵抗。二甲双胍是用于治疗2型糖尿病的最古老的胰岛素增敏剂。在多囊卵巢综合征中，二甲双胍可降低血脂、雄激素和胰岛素水平；诱导排卵和月经周期规律；提高妊娠率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f815/4392089/c6526c24e0bc/JMedLife-08-187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f815/4392089/be1d15430574/JMedLife-08-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f815/4392089/c6526c24e0bc/JMedLife-08-187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f815/4392089/be1d15430574/JMedLife-08-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f815/4392089/c6526c24e0bc/JMedLife-08-187-g002.jpg

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本文引用的文献

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Cellular and molecular mechanisms of metformin: an overview.二甲双胍的细胞和分子机制：概述。
Clin Sci (Lond). 2012 Mar;122(6):253-70. doi: 10.1042/CS20110386.
2
Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society.多毛症的流行病学、诊断和管理：雄激素过多和多囊卵巢综合征学会的共识声明。
Hum Reprod Update. 2012 Mar-Apr;18(2):146-70. doi: 10.1093/humupd/dmr042. Epub 2011 Nov 6.
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The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.
Chin Med. 2024 Dec 31;19(1):180. doi: 10.1186/s13020-024-01034-5.
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The Cardiometabolic Risk in Women with Polycystic Ovarian Syndrome (PCOS): From Pathophysiology to Diagnosis and Treatment.多囊卵巢综合征（PCOS）女性的心脏代谢风险：从病理生理学到诊断和治疗。
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Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.多囊卵巢综合征女性中二甲双胍与肌醇联用对比单用二甲双胍的疗效比较：一项随机对照试验的系统评价与荟萃分析
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Genetic analysis: Therapeutic drug monitoring of metformin and glimepiride on diabetic patients' plasma including genetic polymorphism.基因分析：二甲双胍和格列美脲对糖尿病患者血浆的治疗药物监测，包括基因多态性。
J Adv Pharm Technol Res. 2024 Jul-Sep;15(3):150-155. doi: 10.4103/JAPTR.JAPTR_99_24. Epub 2024 Jul 22.
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Cureus. 2024 Jul 13;16(7):e64498. doi: 10.7759/cureus.64498. eCollection 2024 Jul.
8
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Womens Health (Lond). 2024 Jan-Dec;20:17455057241234530. doi: 10.1177/17455057241234530.
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Pharmacogenet Genomics. 2011 Dec;21(12):837-50. doi: 10.1097/FPC.0b013e32834c0010.
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Cell Metab. 2010 May 5;11(5):390-401. doi: 10.1016/j.cmet.2010.03.014.
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