Palomba Stefano, Falbo Angela, Zullo Fulvio, Orio Francesco
Department of Gynecology and Obstetrics, University "Magna Graecia" of Catanzaro, Via Pio X, 88100 Catanzaro, Italy.
Endocr Rev. 2009 Feb;30(1):1-50. doi: 10.1210/er.2008-0030. Epub 2008 Dec 4.
Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome.
二甲双胍是一种胰岛素增敏剂，广泛用于治疗2型糖尿病患者。由于许多多囊卵巢综合征（PCOS）女性存在胰岛素抵抗，二甲双胍也被引入临床实践用于治疗这些患者。此外，二甲双胍的作用除了胰岛素增敏作用外还有其他靶点。本综述旨在描述二甲双胍在PCOS患者中所有基于证据的和潜在的用途。特别是，我们将分析二甲双胍不仅用于治疗所有与PCOS相关的紊乱，如月经失调、无排卵性不孕、流产增加或妊娠并发症风险、高雄激素血症、子宫内膜、代谢和心血管异常，还用于预防该综合征。
