Balaban Seher, Lee Lisa S, Schreuder Mark, Hoy Andrew J
Discipline of Physiology, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Discipline of Physiology, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia.
Biomed Res Int. 2015;2015:274585. doi: 10.1155/2015/274585. Epub 2015 Mar 19.
Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and how these characteristics may be exploited as therapeutic targets. Much attention has centered on glucose, glutamine and de novo lipogenesis, yet the metabolism of fatty acids that arise from extracellular, as well as intracellular, stores as triacylglycerol has received much less attention. This review focuses on the key pathways of fatty acid metabolism, including uptake, esterification, lipolysis, and mitochondrial oxidation, and how the regulators of these pathways are altered in cancer. Additionally, we discuss the potential link that fatty acid metabolism may serve between obesity and changes in cancer progression.
目前，人们对阐明癌症的代谢特征以及如何将这些特征用作治疗靶点重新产生了兴趣。很多关注都集中在葡萄糖、谷氨酰胺和从头脂肪生成上，然而，作为三酰甘油从细胞外以及细胞内储存中产生的脂肪酸代谢却很少受到关注。本综述重点关注脂肪酸代谢的关键途径，包括摄取、酯化、脂肪分解和线粒体氧化，以及这些途径的调节因子在癌症中是如何改变的。此外，我们还讨论了脂肪酸代谢可能在肥胖与癌症进展变化之间起到的潜在联系。
