灯盏花素与甲钴胺联合治疗糖尿病周围神经病变：中国研究的系统评价与Meta分析
Combined therapy of diabetic peripheral neuropathy with breviscapine and mecobalamin: a systematic review and a meta-analysis of Chinese studies.
作者信息
Zheng Chanjiao, Ou Weilin, Shen Huanyu, Zhou Zhiheng, Wang Jiaji
机构信息
School of Public Health, Guangzhou Medical University, Guangzhou 510182, China.
出版信息
Biomed Res Int. 2015;2015:680756. doi: 10.1155/2015/680756. Epub 2015 Mar 19.
OBJECTIVE
A meta-analysis on combined therapy of diabetic peripheral neuropathy (DPN) with breviscapine and mecobalamin was performed to evaluate the efficacy of this therapy.
METHODS
Six English databases (Medline, Cochrane Library, PubMed, EMBASE, Web of Science, and CINAHL) and four Chinese databases (China National Knowledge Infrastructure, VIP Journals Database, CBM, and Wanfang database) were searched for studies on the clinical trials in which DPN was treated with breviscapine and mecobalamin, and RevMan 5.1 package was employed for analyzing pooled trials and publication bias.
RESULTS
A total of 17 articles including 1398 DPN patients were identified. Homogeneity was observed among different studies (P = 0.74). The efficacy of combined therapy with breviscapine and mecobalamin was significantly better than that in control group [P < 0.0001 (OR = 5.01, 95% CI: 3.70-6.78)].
CONCLUSION
Available findings suggest that the therapeutic efficacy of breviscapine combining mecobalamin is superior to mecobalamin alone, and this strategy is required to be popularized in clinical practice.
目的
对灯盏花素联合甲钴胺治疗糖尿病周围神经病变（DPN）进行荟萃分析，以评估该疗法的疗效。
方法
检索六个英文数据库（Medline、Cochrane图书馆、PubMed、EMBASE、Web of Science和CINAHL）以及四个中文数据库（中国知网、维普期刊数据库、中国生物医学文献数据库和万方数据库），查找关于灯盏花素联合甲钴胺治疗DPN的临床试验研究，并使用RevMan 5.1软件包分析汇总试验及发表偏倚。
结果
共纳入17篇文章，涉及1398例DPN患者。不同研究间具有同质性（P = 0.74）。灯盏花素联合甲钴胺治疗的疗效显著优于对照组[P < 0.0001（OR = �.01，95%CI：3.70 - 6.78）]。
结论
现有研究结果表明，灯盏花素联合甲钴胺的治疗效果优于单用甲钴胺，该治疗策略值得在临床实践中推广。
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