Yosunkaya Şebnem, Okur Hacer Kuzu, Can Ümmügülsüm, Zamani Adil, Kutlu Ruhuşen
1 Meram Medical Faculty, Department of Chest Disease, Necmettin Erbakan University , Konya, Turkey .
2 Department of Chest Diseases and Thoracic Surgery, Fatih Sultan Mehmet Education and Research Hospital , Istanbul, Turkey .
Metab Syndr Relat Disord. 2015 Aug;13(6):272-7. doi: 10.1089/met.2014.0161. Epub 2015 Apr 13.
There is growing evidence that leptin regulation is altered in obstructive sleep apnea syndrome (OSAS). Several potential mechanisms have been purported to explain how sleep apnea may alter leptin levels. We investigated whether repeated apneas, hypoxia, or excessive daytime sleepiness influenced the levels of leptin in OSAS patients. We also evaluated whether a 3-month continuous positive airway pressure (CPAP) treatment affected leptin levels in patients.
Randomly selected 31 untreated, otherwise healthy male, overweight [body mass index (BMI) >25 kg/m(2)] obstructive sleep apnea syndrome (OSAS) patients [apnea-hypopnea index (AHI) ≥15] and 25 control (AHI <5) were included in this study. To confirm the diagnosis, all subjects underwent standard polysomnography. Serum samples were taken at 07:00-08:00 a.m. after overnight fasting. The OSAS patients that had regular CPAP treatment (n=26) were re-evaulated 3 months later.
Leptin levels (50.5±17.5 grams/L in OSAS and 56.3±25.5 grams/L in controls) and lipid profiles (TC, TGs, HDL-C, and LDL-C) between patient and control groups did not differ (P>0.05). Leptin levels were not correlated with the AHI, oxygen saturation, or excessive daytime sleepiness. CPAP treatment did not significantly change the (BMI), waist and neck circumference, or leptin levels in OSAS patients. Furthermore, we found no correlation between the decrease in serum leptin levels and parameters that were improved by CPAP treatment.
Leptin levels and lipid profile of overweight subjects with and without OSAS were not different, and our results suggest that OSAS-related parameters and CPAP treatment do not play a significant role in the serum leptin levels.
越来越多的证据表明，阻塞性睡眠呼吸暂停综合征（OSAS）患者的瘦素调节发生改变。已有多种潜在机制被提出用以解释睡眠呼吸暂停如何改变瘦素水平。我们研究了反复呼吸暂停、低氧血症或日间过度嗜睡是否会影响OSAS患者的瘦素水平。我们还评估了3个月的持续气道正压通气（CPAP）治疗是否会影响患者的瘦素水平。
本研究随机选取了31名未经治疗的、其他方面健康的超重男性[体重指数（BMI）>25kg/m²]阻塞性睡眠呼吸暂停综合征（OSAS）患者[呼吸暂停低通气指数（AHI）≥15]以及25名对照者（AHI<5）。为确诊，所有受试者均接受了标准多导睡眠监测。空腹过夜后，于上午07:00 - 08:00采集血清样本。对接受规律CPAP治疗的OSAS患者（n = 26）在3个月后进行重新评估。
患者组与对照组之间的瘦素水平（OSAS组为50.5±17.5克/升，对照组为56.3±25.5克/升）及血脂谱（总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）并无差异（P>0.05）。瘦素水平与AHI、血氧饱和度或日间过度嗜睡均无相关性。CPAP治疗并未显著改变OSAS患者的体重指数（BMI）、腰围和颈围或瘦素水平。此外，我们发现血清瘦素水平的降低与CPAP治疗改善的参数之间并无相关性。
有或无OSAS的超重受试者的瘦素水平和血脂谱并无差异，我们的结果表明，与OSAS相关的参数及CPAP治疗对血清瘦素水平并无显著影响。
