Dong Y Z, Huang Y X, Lu T
Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Weihui, China
Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Weihui, China.
Genet Mol Res. 2015 Mar 13;14(1):1899-902. doi: 10.4238/2015.March.13.18.
In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the control group (P = 0.011). We also found that the C allele was more common in osteosarcoma patients than that in control subjects (P = 0.004). Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.
在本研究中，我们调查了中国人群中RECQL基因多态性与骨肉瘤之间的关联。我们选择了RECQL5基因中的rs820196，并对185例骨肉瘤患者和201例年龄及性别匹配的非癌症对照者进行了基因分型。我们发现，与对照组相比，骨肉瘤组中CC基因型更为常见（P = 0.011）。我们还发现，骨肉瘤患者中C等位基因比对照受试者更为常见（P = 0.004）。我们的结果表明，RECQL5基因多态性与中国人群中的骨肉瘤相关。
