Kaneoke Y, Koike Y, Sakurai N, Takahashi A, Watanabe S
Department of Neurology, Nagoya University School of Medicine, Japan.
Neurology. 1989 Dec;39(12):1615-8. doi: 10.1212/wnl.39.12.1615.
We studied the onset of preparatory postural responses and subsequent voluntary movements by measuring soleus muscle activities in the standing position in 20 patients with Parkinson's disease. We measured the postural response in preparing to rise on tiptoe as the onset of the premotion silent period (PMSP). Our patients showed no delay when compared with age-matched healthy controls, but did show a significant delay in the onset of voluntary movement. The elongated PMSP (increased duration of the preparatory postural adjustments) was related to the severity of bradykinesia. Results indicate that the conventional reaction time is increased in patients with Parkinson's disease, even though there is no delay of central processing for the preparation of voluntary movements, and that there is bradykinesia of involuntary postural movements.
我们通过测量20例帕金森病患者站立位时比目鱼肌的活动，研究了预备姿势反应的起始以及随后的自主运动。我们将准备踮脚时的姿势反应作为运动前静息期（PMSP）的起始进行测量。与年龄匹配的健康对照组相比，我们的患者在PMSP起始时没有延迟，但在自主运动起始时确实出现了显著延迟。延长的PMSP（预备姿势调整持续时间增加）与运动迟缓的严重程度相关。结果表明，帕金森病患者的传统反应时间增加，即使在准备自主运动的中枢处理过程中没有延迟，并且存在非自主姿势运动的运动迟缓。
