Bazalgette D, Zattara M, Bathien N, Bouisset S, Rondot P
Adv Neurol. 1987;45:371-4.
To determine the extent to which deficits in coordination between posture and movement are influenced by postural disorders, postural adjustments associated with rapid voluntary arm movement were studied in PD patients and controls. EMG activity in postural muscles of the lower limbs and the trunk and local anteroposterior accelerations of the upper part of the leg were recorded in subjects who rapidly raised their arms to a horizontal position in response to a visual signal. The arm movement was characterized electromyographically by EMG activity from the deltoid muscle (anterior portion) and kinetically by acceleration of the arm. Study of characteristics of voluntary movement showed a nonsignificant increase in RT (simple-reaction time task) and an important increase in MT. There were important differences between PD patients and control subjects with regard to postural adjustments. Timing between voluntary movement and postural movement was anticipatory in 5% of PD patients, whereas it was anticipatory in 100% of control subjects. In PD patients, organization of early postural adjustments was not specific to voluntary movement; in control subjects, organization of early postural adjustments was specific to the forthcoming movement. Last, a possible functional relation between the "quality" of postural adjustments and a reduction in motor performance of normal subjects is suggested.
为了确定姿势与运动之间的协调缺陷在多大程度上受姿势障碍的影响，我们对帕金森病患者和对照组进行了与快速自主手臂运动相关的姿势调整研究。在受试者根据视觉信号将手臂快速举至水平位置时，记录其下肢和躯干姿势肌的肌电图活动以及腿部上半部分的局部前后加速度。手臂运动在肌电图上的特征是三角肌（前部）的肌电图活动，在动力学上的特征是手臂的加速度。对自主运动特征的研究表明，反应时间（简单反应时间任务）无显著增加，而运动时间有显著增加。帕金森病患者和对照组在姿势调整方面存在重要差异。在5%的帕金森病患者中，自主运动与姿势运动之间的时间是预期性的，而在100%的对照组中是预期性的。在帕金森病患者中，早期姿势调整的组织并非特定于自主运动；在对照组中，早期姿势调整的组织特定于即将进行的运动。最后，提出了姿势调整“质量”与正常受试者运动表现降低之间可能的功能关系。
