Periodontol 2000. 2015 Jun;68(1):99-121. doi: 10.1111/prd.12077.
The increased use of dental implants and related bone-augmentation procedures creates a need for reliable proof-of-principle preclinical models for evaluating different bone-regenerative techniques. The simulation of clinical scenarios by such models is of importance when the experiments are designed in order for the outcomes to provide basic points of clinical relevance. At the same time, the increased proportion of the population with different chronic diseases of ageing necessitates the need to reproduce these conditions in the same proof-of-principle preclinical models to allow evaluation of the effect of the relevant chronic disease on the bone-healing process. This review presents a number of 'proof-of-principle' preclinical models in health and in chronic systemic conditions in which the guided bone regeneration principle was evaluated.
种植牙和相关的骨增量手术的应用日益增多，这就需要可靠的、基于原理的临床前模型来评估不同的骨再生技术。在设计实验时，通过这些模型模拟临床场景非常重要，这样实验结果才能提供基本的临床相关性要点。同时，患有不同慢性老年疾病的人群比例增加，这就需要在相同的基于原理的临床前模型中再现这些条件，以评估相关慢性疾病对骨愈合过程的影响。本综述介绍了一些“基于原理”的临床前模型，包括健康和慢性系统性疾病条件下，评估引导骨再生原理的模型。
