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[糖尿病学中的新技术。我们离闭环还有多远?]

[New technologies in diabetology. How far are we from a closed loop?].

作者信息

Freckmann G

机构信息

Institut für Diabetes-Technologie, Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm, Helmholtzstr. 20, 89081, Ulm, Deutschland,

出版信息

Internist (Berl). 2015 May;56(5):484-92. doi: 10.1007/s00108-014-3627-2.

Abstract

Today, assistive technologies are highly important in the treatment of diabetes, especially in the therapy of type 1 diabetes. The use of insulin pumps, for example, has become an established form of treatment. Modern insulin pumps offer various functions, such as different basal rate profiles, split delivery of the meal bolus, and integrated bolus calculators. Some pumps are additionally connected to a blood glucose meter or a continuous glucose-monitoring sensor. Several minimally invasive needle-type sensor systems for continuous tissue glucose monitoring are already available. Recent developments aim at increasing the functionality of insulin pumps and the improvements of sensors for continuous glucose monitoring. In addition, many research groups are working on closing the loop between these two components and thus developing an artificial pancreas, which automatically regulates insulin delivery. The first steps have already been taken and bolus calculators or sensor-augmented insulin pumps with suspension of insulin delivery are now available. Many experimental models show promising results. Prior to the implementation of a fully automated system for everyday use, however, partially automated systems that require user input are to be expected. This article aims at giving an overview of the current state of development in the field of diabetes technology.

摘要

如今,辅助技术在糖尿病治疗中极为重要,尤其是在1型糖尿病的治疗方面。例如,胰岛素泵的使用已成为一种既定的治疗方式。现代胰岛素泵具备多种功能,如不同的基础输注率模式、餐时大剂量胰岛素的分次输注以及集成的大剂量胰岛素计算器。一些泵还额外连接了血糖仪或连续血糖监测传感器。目前已有几种用于连续组织葡萄糖监测的微创针型传感器系统。近期的发展旨在增强胰岛素泵的功能以及改进连续血糖监测传感器。此外,许多研究团队正在致力于实现这两个组件之间的闭环,从而开发出能自动调节胰岛素输注的人工胰腺。已经迈出了第一步,现在有了大剂量胰岛素计算器或能暂停胰岛素输注的传感器增强型胰岛素泵。许多实验模型都显示出了有前景的结果。然而,在实现可供日常使用的全自动系统之前,预计会出现需要用户输入的部分自动化系统。本文旨在概述糖尿病技术领域的当前发展状况。

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