Dube Simmi, Errazuriz-Cruzat Isabel, Basu Ananda, Basu Rita
Gandhi Medical College, Bhopal, MP, India.
Curr Diab Rep. 2015 Jun;15(6):605. doi: 10.1007/s11892-015-0605-6.
Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and action (e.g. type 2 diabetes), the degree of SG assumes increasing significance in determining the level of glucose tolerance both in fasted and postprandial states. Although the importance of SG has been recognized for years, mechanisms that contribute to SG are poorly understood. Research data on modulation of SG and its impact in glucose intolerance is limited. In this review, we will focus on the role of SG in the regulation of glucose tolerance, its evaluation, and potential advantages of therapies that can enhance glucose-induced stimulation of glucose uptake and suppression of its own production in conditions of impaired insulin secretion and action.
葡萄糖效能（SG）是指在基础/恒定胰岛素浓度下，葡萄糖自身刺激其摄取并抑制其生成的能力。在个体中，葡萄糖耐量是胰岛素分泌、胰岛素作用和SG的函数。在胰岛素分泌和作用下降的情况下（如2型糖尿病），SG程度在决定空腹和餐后状态下的葡萄糖耐量水平方面具有越来越重要的意义。尽管SG的重要性已被认识多年，但对其产生机制了解甚少。关于SG调节及其对葡萄糖不耐受影响的研究数据有限。在本综述中，我们将重点关注SG在葡萄糖耐量调节中的作用、其评估，以及在胰岛素分泌和作用受损的情况下，能够增强葡萄糖诱导的葡萄糖摄取刺激和抑制其自身生成的治疗方法的潜在优势。
