点击反应促进抗利什曼原虫三唑基O-苄基槲皮素糖缀合物的合成。
Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates.
作者信息
Dwivedi Pratibha, Mishra Kunj B, Mishra Bhuwan B, Singh Nisha, Singh Rakesh K, Tiwari Vinod K
机构信息
Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India.
出版信息
Glycoconj J. 2015 May;32(3-4):127-40. doi: 10.1007/s10719-015-9582-x. Epub 2015 Apr 14.
The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani. Graphical Abstract Click Inspired Synthesis of Antileishmanial Triazolyl O-Benzylquercetin Glycoconjugates.
研究了脱氧叠氮糖1与O-苄基槲皮素炔烃（5-7）进行1,3-偶极环加成反应，在二氯甲烷中CuI/DIPEA存在下生成区域选择性三唑连接的O-苄基槲皮素糖缀合物（8-10）。对所有合成的糖缀合物（8-10）进行了针对杜氏利什曼原虫前鞭毛体和无鞭毛体的抗利什曼活性评估。图形摘要 点击 抗利什曼三唑基O-苄基槲皮素糖缀合物的启发式合成。
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