Enayatollahi Mohammad Ali, Novack Thomas A, Maltenfort Mitchell G, Tabatabaee Reza Mostafavi, Chen Antonia F, Parvizi Javad
The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
J Arthroplasty. 2015 Aug;30(8):1308-12. doi: 10.1016/j.arth.2015.03.031. Epub 2015 Apr 1.
Given the growing patient population with hemoglobinopathies needing total joint arthroplasty (TJA) and paucity of literature addressing this cohort, we examined the in-hospital complications in patients with hemoglobinopathies undergoing TJA. International Classification of Diseases, Ninth Revision codes were used to search the Nationwide Inpatient Sample database for hemoglobinopathy patients undergoing primary or revision TJA. Hemoglobinopathy patients had a significant increase in cardiac, respiratory, and wound complications; blood product transfusion; pulmonary embolism; surgical site infection; and systemic infection events, while there was no significant effect on deaths, deep vein thrombosis, and renal complications. It may be prudent to implement blood conservation strategies as well as diligent postoperative protocols to minimize the need for transfusion and related complications in this patient population.
鉴于需要进行全关节置换术（TJA）的血红蛋白病患者群体不断增加，且针对该群体的文献较少，我们研究了接受TJA的血红蛋白病患者的院内并发症。使用国际疾病分类第九版编码在全国住院患者样本数据库中搜索接受初次或翻修TJA的血红蛋白病患者。血红蛋白病患者在心脏、呼吸和伤口并发症、血液制品输血、肺栓塞、手术部位感染和全身感染事件方面显著增加，而对死亡、深静脉血栓形成和肾脏并发症没有显著影响。在该患者群体中实施血液保护策略以及严格的术后方案以尽量减少输血需求和相关并发症可能是谨慎的做法。
