J波综合征：Brugada综合征和早期复极综合征。
J-wave syndromes: Brugada and early repolarization syndromes.
作者信息
Antzelevitch Charles, Yan Gan-Xin
机构信息
SUNY Upstate Medical University, Syracuse, New York.
Lankenau Institute for Medical Research and Lankenau Medical Center, Wynnewood, Pennsylvania; Jefferson Medical College, Philadelphia, Pennsylvania; The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China.
出版信息
Heart Rhythm. 2015 Aug;12(8):1852-66. doi: 10.1016/j.hrthm.2015.04.014. Epub 2015 Apr 11.
Abstract
A prominent J wave is encountered in a number of life-threatening cardiac arrhythmia syndromes, including the Brugada syndrome and early repolarization syndromes. Brugada syndrome and early repolarization syndromes differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J-wave syndromes. Despite two decades of intensive research, risk stratification and the approach to therapy of these 2 inherited cardiac arrhythmia syndromes are still undergoing rapid evolution. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, and molecular, ionic, cellular, and genetic mechanisms underlying these 2 fascinating syndromes that have captured the interest and attention of the cardiology community in recent years.
摘要
在包括Brugada综合征和早期复极综合征在内的多种危及生命的心律失常综合征中会出现明显的J波。Brugada综合征和早期复极综合征在异常J波的幅度和导联位置方面有所不同，被认为代表了一种称为J波综合征的连续表型表达谱。尽管经过了二十年的深入研究，但这两种遗传性心律失常综合征的风险分层和治疗方法仍在快速发展。我们撰写这篇综述的目的是对这两种近年来引起心脏病学界兴趣和关注的迷人综合征的临床特征、风险分层因素以及分子、离子、细胞和遗传机制进行综合概述。
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