Cherikchi L E
Oftalmol Zh. 1989(5):304-7.
The paper describes results after a study of pathochemical disturbances of diabetic hyperglycemia on a model of alloxan diabetes. Sugar and amino nitrogen contents in the aqueous humor of the anterior chamber, anterior and posterior segments of the crystalline lens, the iris, ciliary body, choroid and the retina were studied and the data obtained were compared with quantitative contents of sugar and amino nitrogen in the eliminate from the eyes of experimental animals. High amounts of sugar and amino nitrogen, infrequently exceeding 2-3 times in controls, were found to appear in the aqueous humor of the anterior chamber, the crystalline lens, the vitreous body. In all tests the sugar and amino nitrogen contents in the posterior segment of the lens was 10-12% higher than in its anterior segment. The data obtained about accumulation of sugar and amino nitrogen mainly in tissues and media of the eye (the lens, the vitreous) affected by diabetic process already at its early stages widen the knowledge about pathogenesis of the process and peculiarities of its pathochemistry.
本文描述了在四氧嘧啶糖尿病模型上对糖尿病高血糖的病理化学紊乱进行研究后的结果。研究了前房房水、晶状体前后节、虹膜、睫状体、脉络膜和视网膜中的糖和氨基氮含量，并将所得数据与实验动物眼内液中糖和氨基氮的定量含量进行了比较。发现前房房水、晶状体、玻璃体中出现大量的糖和氨基氮，其含量很少超过对照组的2 - 3倍。在所有测试中，晶状体后节中的糖和氨基氮含量比其前节高10 - 12%。所获得的关于糖和氨基氮主要在糖尿病早期就已受影响的眼组织和介质（晶状体、玻璃体）中积累的数据，拓宽了对该疾病发病机制及其病理化学特性的认识。
