循环利用的白细胞介素-7可传递至邻近的T细胞。
Recycled IL-7 Can Be Delivered to Neighboring T Cells.
作者信息
Bazdar Douglas A, Kalinowska Magdalena, Panigrahi Soumya, Sieg Scott F
机构信息
Division of Infectious Diseases and HIV Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and.
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
出版信息
J Immunol. 2015 May 15;194(10):4698-704. doi: 10.4049/jimmunol.1400560. Epub 2015 Apr 13.
IL-7 is a key homeostatic cytokine that provides signals for T cell survival and proliferation in vivo. In this article, we provide evidence that IL-7 utilization is enhanced by a novel mechanism of cytokine "recycling" during which T cells treated with rIL-7 are rapidly induced to express p-STAT5 and are subsequently able to recycle biologically active cytokine for release to neighboring cells in soluble form. Our observations indicate that the ability of cells to recycle IL-7 is dependent on IL-7R α-chain (CD127) and endocytosis, consistent with a model whereby IL-7 is internalized via receptor interactions before recycling. These observations provide evidence of a novel mechanism that enables cells to optimally use IL-7.
白细胞介素-7（IL-7）是一种关键的稳态细胞因子，在体内为T细胞的存活和增殖提供信号。在本文中，我们提供证据表明，通过一种新型的细胞因子“循环利用”机制可增强IL-7的利用，在此过程中，用重组IL-7（rIL-7）处理的T细胞会迅速被诱导表达磷酸化信号转导和转录激活因子5（p-STAT5），随后能够将生物活性细胞因子循环利用，以可溶性形式释放到邻近细胞中。我们的观察结果表明，细胞循环利用IL-7的能力取决于IL-7受体α链（CD127）和内吞作用，这与IL-7在循环利用前通过受体相互作用被内化的模型一致。这些观察结果为细胞最佳利用IL-7的新机制提供了证据。
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