Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Semin Immunol. 2012 Jun;24(3):209-17. doi: 10.1016/j.smim.2012.04.010. Epub 2012 May 1.
After their development in the thymus, mature T cells are maintained in the periphery by two sets of survival signals, namely TCR signals from contact with self-peptide/MHC ligands and the cytokine receptor signals from binding IL-7 and IL-15. These signals cooperate to maximize the utility of finite resources to support a diverse pool of mature T cells. It is becoming increasingly clear that multiple mechanisms exist to regulate expression of IL-7R at the transcriptional and post-translational levels. The interplay between TCR signals and IL-7R signals are also important in regulation of IL-7R expression. This review will focus on regulation of T cell homeostasis by IL-7R signaling, with an emphasis on the cross talk between signals from TCR and IL-7R.
在胸腺中发育成熟后，T 细胞通过两套生存信号在周围组织中得以维持，分别是 TCR 与自身肽/MHC 配体结合所产生的信号，以及与 IL-7 和 IL-15 结合所产生的细胞因子受体信号。这些信号共同作用，最大限度地利用有限的资源来支持多样化的成熟 T 细胞群体。目前越来越清楚的是，存在多种机制可以在转录和翻译后水平上调节 IL-7R 的表达。TCR 信号和 IL-7R 信号之间的相互作用对于 IL-7R 表达的调节也很重要。这篇综述将重点关注 IL-7R 信号对 T 细胞稳态的调节，特别强调 TCR 和 IL-7R 信号之间的串扰。
