Mastrangelo D, Di Pisa F, Hadjistilianou T, Bardelli A M, Silvestri S, Frezzotti R
Centro Ricerche Sclavo, Siena, Italy.
Ophthalmic Paediatr Genet. 1989 Sep;10(3):161-71. doi: 10.3109/13816818909009872.
A series of 75 retinoblastoma patients were analyzed at the Institute of Ophthalmology, Siena, and a mathematical model for the 'nodule to cancer' transformation applied to it. The authors obtained data in disagreement with Knudson's 'two hit' hypothesis but fitting an alternative model of oncogenesis. This model is based on probabilistic arguments and a possible pattern of tumor growth and evolution is given in detail.
