Bonaïti-Pellie C, Briard-Guillemot M L, Feingold J, Frezal J
J Natl Cancer Inst. 1976 Aug;57(2):269-76. doi: 10.1093/jnci/57.2.269.
To test Knudson's hypothesis that two successive mutations are involved in retinoblastoma, we studied the data on 899 cases. Some of the findings appeared to differ from those that might be expected if Knudson's hypothesis were correct. Certain criticisms of Knudson's methodology and model were suggested. Alternative explanations proposed were 1) the role of the sequence in which mutations occur, and 2) the possibility of three mutational events.
为了验证克努森关于视网膜母细胞瘤涉及两个连续突变的假说，我们研究了899例病例的数据。如果克努森的假说是正确的，一些研究结果似乎与预期的不同。有人对克努森的方法和模型提出了某些批评。提出的其他解释是：1）突变发生顺序的作用；2）三个突变事件的可能性。
