Tosi P, Cintorino M, Toti P, Ninfo V, Montesco M C, Frezzotti R, Hadjistilianou T, Acquaviva A, Barbini P
Institute of Pathological Anatomy, University of Siena, Italy.
Ophthalmic Paediatr Genet. 1989 Sep;10(3):173-7. doi: 10.3109/13816818909009873.
In the present study histologic, clinical and follow-up data of 37 cases of retinoblastoma were statistically analyzed by means of a multivariate method. The evaluated histological parameters were: growth pattern, degree of differentiation, number of mitoses, presence of necrosis, pseudorosettes, blood vessel basophilia, calcification, extension to anterior chamber, invasion of optic nerve and ocular coats (choroid and sclera). The analysis was based upon the Cox proportional hazards regression model. Invasion of ocular coats proved to be highly correlated to the prognosis (p less than 0.0002). None of the other parameters showed a significant relation to survival.
在本研究中，采用多变量方法对37例视网膜母细胞瘤的组织学、临床及随访数据进行了统计分析。评估的组织学参数包括：生长模式、分化程度、有丝分裂数、坏死情况、假菊形团、血管嗜碱性、钙化、前房扩展、视神经侵犯以及眼外膜（脉络膜和巩膜）侵犯。分析基于Cox比例风险回归模型。结果表明，眼外膜侵犯与预后高度相关（p小于0.0002）。其他参数均未显示与生存率有显著关系。
