Grunwald J E, Brucker A J, Petrig B L, Riva C E
Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Ophthalmology. 1989 Oct;96(10):1518-22. doi: 10.1016/s0161-6420(89)32697-2.
Bidirectional laser Doppler velocimetry and monochromatic fundus photography were used to investigate retinal hemodynamics before and after panretinal photocoagulation (PRP) in 25 eyes of 23 diabetic patients with proliferative retinopathy. After PRP, there was a significant decrease in retinal volumetric blood flow rate and an increase in the retinal vascular regulatory response to hyperoxia (R). A significant association was found between the presence or absence of regression of neovascularization and the increase or decrease in R after PRP. Eyes that showed regression of neovascularization had significantly larger average R after PRP than eyes that did not show regression. Lack of improvement in R after PRP may be related to the presence of remaining ischemia or hypoxia in eyes that continue to show proliferation after PRP.
采用双向激光多普勒测速法和单色眼底照相术，对23例增殖性视网膜病变糖尿病患者的25只眼睛进行全视网膜光凝（PRP）前后的视网膜血流动力学研究。PRP后，视网膜体积血流速率显著降低，视网膜血管对高氧的调节反应（R）增加。发现新生血管消退与否与PRP后R的增加或减少之间存在显著关联。新生血管消退的眼睛PRP后的平均R显著大于未消退的眼睛。PRP后R无改善可能与PRP后仍有增殖表现的眼睛中存在残留缺血或缺氧有关。
