Mayock D E, Twiggs G A, Standaert T A, Watchko J F, Woodrum D E
Department of Pediatrics, University of Washington, Seattle 98195.
Pediatr Res. 1989 Sep;26(3):196-9. doi: 10.1203/00006450-198909000-00005.
The effect of aminophylline on diaphragmatic blood flow was investigated in two groups of newborn piglets. Six animals were studied during spontaneous breathing and seven additional animals were paralyzed and ventilated to assess the effect of aminophylline on blood flow to the nonworking diaphragm. Arterial blood gases and pH, cardiac output, and diaphragmatic blood flow were measured before and 20 min after infusion of 20 mg/kg aminophylline. Blood theophylline concentrations averaged 117 mumols/L (21 micrograms/mL) in both groups of animals. Heart rate increased significantly in all animals. Cardiac output increased significantly only in spontaneously breathing animals. Aminophylline had no effect on blood flow to the costal or crural portions of the diaphragm in either the paralyzed or spontaneously breathing animals.
在两组新生仔猪中研究了氨茶碱对膈肌血流量的影响。六只动物在自主呼吸期间进行了研究，另外七只动物被麻痹并进行机械通气，以评估氨茶碱对非工作状态膈肌血流量的影响。在输注20mg/kg氨茶碱之前和之后20分钟，测量动脉血气和pH值、心输出量以及膈肌血流量。两组动物的血中茶碱浓度平均为117μmol/L（21μg/mL）。所有动物的心率均显著增加。仅在自主呼吸的动物中心输出量显著增加。氨茶碱对麻痹或自主呼吸的动物的膈肌肋部或膈脚部的血流量均无影响。
