Swift A V, Cohen M J, Hynd G W, Wisenbaker J M, McKie K M, Makari G, McKie V C
Department of Neurology, Medical College of Georgia, Augusta 30912.
Pediatrics. 1989 Dec;84(6):1077-85.
In this study, the neuropsychologic functioning of 21 children with sickle cell anemia and 21 sibling controls, age range 7 through 16 years, with no history of neurologic disease, was examined. Outcome measures included tests of intelligence, constructional praxis, memory, and academic learning. On the Wechsler Intelligence Scale for Children--Revised, the sickle cell group had a mean Full Scale IQ of 77.7 (SD 12.4) compared with 94.3 (SD 11.0) for the control group. The profile of test scores was similar for the two groups, with the sickle cell group scoring significantly lower than the control group on almost all cognitive measures. Both groups showed academic achievement to be commensurate with their measured intellectual ability. These results suggest that subtle but significant and widespread neuropsychologic deficits are associated with sickle cell anemia even in the absence of neurologic complications. When and by what process this neuropsychologic impairment is caused needs to be determined.
在本研究中，对21名患有镰状细胞贫血的儿童以及21名年龄在7至16岁之间、无神经疾病史的同胞对照者的神经心理功能进行了检查。结果测量包括智力测试、构建实践、记忆和学业学习测试。在韦氏儿童智力量表修订版测试中，镰状细胞组的平均全量表智商为77.7（标准差12.4），而对照组为94.3（标准差11.0）。两组的测试分数分布相似，镰状细胞组在几乎所有认知测量上的得分均显著低于对照组。两组的学业成绩都与其测量出的智力能力相当。这些结果表明，即使没有神经并发症，镰状细胞贫血也会伴有细微但显著且广泛的神经心理缺陷。这种神经心理损伤是何时以及通过何种过程造成的，还有待确定。
