Gürkan Asuman, Özlü Sare Gülfem, Altıaylık-Özer Pınar, Kurtul Bengi Ece, Karacan Can Demir, Şenel Saliha
Department of Dermatology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Department of Pediatric Nephrology and Rheumatology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Pediatr Dermatol. 2015 Jul-Aug;32(4):476-80. doi: 10.1111/pde.12577. Epub 2015 Apr 15.
Recurrent aphthous stomatitis (RAS) is a common oral ulcerative condition in children. The objective was to describe the clinical features of RAS in children with accompanying clinical and laboratory findings.
The study included 120 patients younger than 18 years of age (mean age 9.6 ± 4.3 years) with three or more oral aphthous ulcers per year between August 2008 and February 2014. Demographic characteristics of the patients, clinical features of the ulcers, and associated clinical and laboratory findings were evaluated.
The mean number of aphthae per year was 12.8 ± 8.5 and the mean duration of the disease was 3.6 ± 2.9 years. Minor aphthae were the most common type (87%), papulopustules were the most common accompanying cutaneous lesions (13.3%), and family history of RAS was the most common associated factor (35.8%). Genital scarring (p = 0.04) and pathergy (p = 0.01) were significantly more common in the adolescent group. Pathergy was significantly related to genital scarring (p = 0.04) and Behçet's disease (p = 0.02). There was no association between the number of aphthae per year and the duration of the disease and hematologic and immunologic abnormalities.
Our study is consistent with previous reports in terms of clinical features of aphthous ulcers, related diseases, and family history of RAS, but no associated laboratory abnormalities were noted.
复发性阿弗他口炎（RAS）是儿童常见的口腔溃疡性疾病。目的是描述伴有临床和实验室检查结果的儿童RAS的临床特征。
该研究纳入了2008年8月至2014年2月期间120例年龄小于18岁（平均年龄9.6±4.3岁）、每年有3次或更多次口腔阿弗他溃疡的患者。评估了患者的人口统计学特征、溃疡的临床特征以及相关的临床和实验室检查结果。
每年阿弗他溃疡的平均数量为12.8±8.5，疾病的平均持续时间为3.6±2.9年。轻型阿弗他溃疡是最常见的类型（87%），丘疹脓疱是最常见的伴发皮肤损害（13.3%），RAS家族史是最常见的相关因素（35.8%）。生殖器瘢痕形成（p = 0.04）和同形反应（p = 0.01）在青少年组中明显更常见。同形反应与生殖器瘢痕形成（p = 0.04）和白塞病（p = 0.02）显著相关。每年阿弗他溃疡的数量与疾病持续时间以及血液学和免疫学异常之间无关联。
我们的研究在阿弗他溃疡的临床特征、相关疾病和RAS家族史方面与先前的报告一致，但未发现相关的实验室异常。
