Department of Stomatology, Jiangmen Maternal and Child Health Hospital (Jiangmen Children's Hospital), Jiangmen, Guangdong, China.
Prevention and Healthcare, Jiangmen Municipal Stomatological Hospital, Jiangmen, Guangdong, China.
Braz J Med Biol Res. 2020 Jun 26;53(8):e9886. doi: 10.1590/1414-431X20209886. eCollection 2020.
The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes of oral aphthous ulcers per year and were treated with HA (n=52) or dexamethasone (n=52) from August 15, 2014 to September 3, 2018. Therapy efficacy was evaluated based on the ulcer size and pain score before versus 7 days after either therapy. The paired t-test, chi-squared test, and independent t-test were utilized for statistical analyses. There was no significant difference in ulcer size or pain score between the HA and dexamethasone groups, on day 1 or day 7. Both treatments were tolerated well and no side effects were reported. No significant differences in body temperature, respiration rate, pulse, or systolic/diastolic blood pressure were observed between the start (day 1) and end of treatment (day 7), for either treatment. HA and dexamethasone showed similar efficacy in reducing ulcer size and pain scores, and were tolerated equally well in children with RAU. Future high-quality studies with larger numbers of patients are needed to confirm our findings.
本研究旨在比较 0.2%透明质酸（HA）局部凝胶和地塞米松局部软膏在治疗儿童复发性口腔溃疡（RAU）中的安全性和疗效。这项回顾性观察研究纳入了 104 名每年有两次以上口腔阿弗他溃疡发作的患者，他们于 2014 年 8 月 15 日至 2018 年 9 月 3 日接受 HA（n=52）或地塞米松（n=52）治疗。根据治疗前后 7 天的溃疡大小和疼痛评分评估治疗效果。采用配对 t 检验、卡方检验和独立 t 检验进行统计学分析。HA 组和地塞米松组在第 1 天或第 7 天，溃疡大小或疼痛评分均无显著差异。两种治疗方法均耐受良好，均未报告不良反应。在治疗开始（第 1 天）和结束（第 7 天）时，对于任何一种治疗方法，体温、呼吸频率、脉搏或收缩压/舒张压均无显著差异。HA 和地塞米松在减轻溃疡大小和疼痛评分方面具有相似的疗效，在治疗 RAU 儿童方面具有相同的耐受性。需要未来开展高质量、大样本量的研究来证实我们的发现。
