Hoffman Melissa B, Farhangian Michael, Feldman Steven R
Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Expert Rev Clin Immunol. 2015 Jun;11(6):709-20. doi: 10.1586/1744666X.2015.1037742. Epub 2015 Apr 15.
The treatment of psoriasis in pregnant women can be challenging. Psoriasis generally improves during pregnancy; however, many pregnant patients still require treatment. In treating pregnant patients, the benefits of treatment and risks to the mother and the fetus must be considered. For localized psoriasis, topical corticosteroids are the treatment of choice. Other topical agents that are approved for the treatment of psoriasis, such as topical tar products and topical tazarotene, should be avoided during pregnancy because of unclear risks of teratogenicity. For moderate-to-severe psoriasis, ultraviolet B phototherapy is preferred. Despite limited safety data, biologics are favored over other systemic medications when needed. While there are new treatment options for psoriasis, there is limited information on the safety of medications during pregnancy.
孕妇银屑病的治疗颇具挑战性。银屑病通常在孕期会有所改善；然而，许多孕妇患者仍需治疗。在治疗孕妇时，必须考虑治疗的益处以及对母亲和胎儿的风险。对于局限性银屑病，外用糖皮质激素是首选治疗方法。其他已获批用于治疗银屑病的外用药物，如外用焦油产品和外用他扎罗汀，由于致畸风险不明，孕期应避免使用。对于中重度银屑病，优先选择紫外线B光疗。尽管安全性数据有限，但在必要时，生物制剂比其他全身用药更受青睐。虽然有针对银屑病的新治疗选择，但关于孕期用药安全性的信息有限。
