鳞状细胞癌的肾小球内微转移
Intraglomerular micrometastasis of squamous cell carcinoma.
作者信息
Sasaki Kotaro, Kumar Sajal, Chenal Mario E, Nicosia Roberto F
机构信息
Department of Pathology , University of Washington Medical Center, Seattle, WA , USA.
Pacific Northwest University of Health Sciences , Yakima, WA 98901 , USA.
出版信息
Clin Kidney J. 2012 Aug;5(4):292-6. doi: 10.1093/ckj/sfs051.
Intraglomerular metastasis is a rare manifestation of disseminated malignancies. We present here a case of intraglomerular metastatic carcinoma diagnosed as an incidental finding on a kidney biopsy in a 62-year-old male presenting with acute renal failure and metastatic penile squamous cell carcinoma. A proliferative lesion composed of highly atypical epithelial cells was found within a capillary loop and adjacent urinary space of an isolated glomerulus, which was immunoreactive for markers of squamous cell carcinoma. This case is a reminder that circulating cancer cells can occasionally lodge in glomeruli and appear as micrometastasis in kidney biopsies performed for the evaluation of renal dysfunction.
肾小球内转移是播散性恶性肿瘤的一种罕见表现。我们在此报告一例肾小球内转移性癌，该病例是在一名62岁患有急性肾衰竭和转移性阴茎鳞状细胞癌的男性患者的肾脏活检中偶然发现的。在一个孤立肾小球的毛细血管袢和相邻尿腔内发现了由高度非典型上皮细胞组成的增殖性病变，该病变对鳞状细胞癌标志物呈免疫反应性。该病例提醒我们，循环癌细胞偶尔可滞留于肾小球，并在为评估肾功能障碍而进行的肾脏活检中表现为微转移。
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