Novara Giacomo, Galfano Antonio, De Marco Vincenzo, Artibani Walter, Ficarra Vincenzo
Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Monoblocco Ospedaliero, Via Giustiniani 2, 35128 Padua, Italy.
Nat Clin Pract Urol. 2007 Mar;4(3):140-6. doi: 10.1038/ncpuro0751.
Squamous cell carcinoma (SCC) of the penis is an uncommon disease in the US and Europe. Without treatment, patients with penile SCC usually die within 2 years after diagnosis of the primary lesion, because of uncontrollable locoregional disease or from distant metastases. The spread of the tumor to the locoregional lymph nodes (lymph-node positivity) is the most relevant prognostic factor. With the available treatments, 5-year cancer-specific survival probabilities are between 75% and 93% for those patients with clinically node-negative disease, and progressively lower for those with increasingly extensive node-positive disease. Similarly, patients with pathologically proven negative nodes have 5-year cancer-specific survival probabilities ranging from 85% to 100%. While patients with a single positive superficial lymph node on pathology have very good cancer-related outcomes, patients with multiple involved lymph nodes have significantly less favorable outcomes. This article focuses on the most important issues that surround the prognosis of squamous cell carcinoma of the penis, with special attention to the prognostic nomograms for penile cancer patients published in 2006.
阴茎鳞状细胞癌（SCC）在美国和欧洲是一种罕见疾病。未经治疗的阴茎鳞状细胞癌患者通常在原发性病变诊断后2年内死亡，原因是局部区域疾病无法控制或发生远处转移。肿瘤扩散至局部区域淋巴结（淋巴结阳性）是最相关的预后因素。采用现有治疗方法，临床淋巴结阴性的患者5年癌症特异性生存概率在75%至93%之间，而淋巴结阳性且病情逐渐加重的患者生存概率则逐渐降低。同样，病理证实淋巴结阴性的患者5年癌症特异性生存概率在85%至100%之间。虽然病理检查发现单个浅表淋巴结阳性的患者癌症相关预后非常好，但多个淋巴结受累的患者预后明显较差。本文重点关注围绕阴茎鳞状细胞癌预后的最重要问题，特别关注2006年发表的阴茎癌患者预后列线图。
