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A new aliphatic alcohol and cytotoxic chemical constituents from Acorus gramineus rhizomes.

作者信息

Kim Ki Hyun, Kang Hee Rae, Eom Hee Jeong, Kim Chung Sub, Choi Sang Un, Lee Kang Ro

机构信息

a Natural Products Laboratory, School of Pharmacy , Sungkyunkwan University , Suwon , Korea.

出版信息

Biosci Biotechnol Biochem. 2015;79(9):1402-5. doi: 10.1080/09168451.2015.1031079. Epub 2015 Apr 15.

DOI:10.1080/09168451.2015.1031079
PMID:25874728
Abstract

A new aliphatic alcohol, (2R,6R)-oct-7-ene-2,6-diol (1), and seven other known compounds (2-8) were isolated from Acorus gramineus rhizomes. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including 2D NMR, HR-MS, and the modified Mosher's method. Compounds 3-8 displayed consistent antiproliferative activities against the cell lines tested with IC50 values ranging from 7 to 48 μm.

摘要

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