Ylinen M, Hanhijärvi H, Jaakonaho J, Peura P
Department of Pharmaceutical Chemistry, University of Kuopio, Finland.
Pharmacol Toxicol. 1989 Oct;65(4):274-7. doi: 10.1111/j.1600-0773.1989.tb01172.x.
The urinary excretion of perfluorooctanoic acid (PFOA) was studied in male Wistar rats after castration and oestradiol administration as well as in intact females and males. During the first 24 hr females excreted 72 +/- 5% (N = 6) of a single intraperitoneal dose of PFOA (50 mg/kg) in urine whereas the intact males excreted only 9 +/- 4% (N = 6). After castration followed by oestradiol administration (500 micrograms/kg every 2nd day for 14 days), the males excreted PFOA in urine in similar amounts as the females (68 +/- 14% at 24 hr, N = 10). Oestradiol treatment of non-castrated males produced similar results (61 +/- 19% at 24 hr, N = 10). Also castration without oestradiol administration significantly enhanced the renal PFOA excretion, but not as effectively as oestradiol treatment. After 96 hr, the concentration of PFOA in serum of intact males was 17-40 times higher than in the serum of other groups. PFOA was similarly bound by the proteins in the serum of females and males. Phase II metabolism of PFOA was not shown either in males or females.
研究了去势和给予雌二醇后雄性Wistar大鼠以及完整雌性和雄性大鼠中全氟辛酸（PFOA）的尿排泄情况。在最初的24小时内，雌性大鼠经腹膜内单次注射PFOA（50毫克/千克）后，尿液中排泄了72±5%（N = 6），而完整雄性大鼠仅排泄了9±4%（N = 6）。去势后给予雌二醇（每2天500微克/千克，共14天），雄性大鼠尿液中PFOA的排泄量与雌性大鼠相似（24小时时为68±14%，N = 10）。对未去势雄性大鼠进行雌二醇处理也产生了类似结果（24小时时为61±19%，N = 10）。同样，未给予雌二醇的去势也显著增强了肾脏对PFOA的排泄，但效果不如雌二醇处理。96小时后，完整雄性大鼠血清中PFOA的浓度比其他组血清中的浓度高17 - 40倍。雌性和雄性大鼠血清中的蛋白质对PFOA的结合情况相似。无论是雄性还是雌性大鼠，均未显示出PFOA的II相代谢。
