Ylinen M, Auriola S
Department of Pharmaceutical Chemistry, University of Kuopio, Finland.
Pharmacol Toxicol. 1990 Jan;66(1):45-8. doi: 10.1111/j.1600-0773.1990.tb00700.x.
Tissue distribution, metabolism, and excretion of perfluorodecanoic acid (PFDA) after a single intraperitoneal dose (20 mg/kg) were studied in female and male Wistar rats. PFDA accumulated in the serum and tissues of the rats. In the serum, more than 99% of PFDA was bound by the serum proteins. In the liver, anionic and esterified PFDA were detected. Metabolic oxidation of PFDA was not observed. PFDA was not excreted in urine either by females or males during 14 days after the administration. At the same time, about 0.5% of the administered PFDA dose was excreted daily in the faeces by both sexes. In spite of the analogical structure with perfluorooctanoic acid (PFOA), which is rapidly eliminated in urine by the female rats, PFDA accumulated similarly in females and males. The reduced elimination of PFDA partially explains its greater toxicity to rats in comparison with PFOA.
在雌性和雄性Wistar大鼠中研究了单次腹腔注射剂量（20mg/kg）全氟癸酸（PFDA）后的组织分布、代谢和排泄情况。PFDA在大鼠的血清和组织中蓄积。在血清中，超过99%的PFDA与血清蛋白结合。在肝脏中，检测到了阴离子型和酯化型PFDA。未观察到PFDA的代谢氧化。给药后14天内，雌性和雄性大鼠的尿液中均未排出PFDA。同时，两性每天约有0.5%的给药PFDA剂量经粪便排出。尽管PFDA与全氟辛酸（PFOA）结构类似，而雌性大鼠可迅速通过尿液将PFOA排出，但PFDA在雌性和雄性大鼠中的蓄积情况相似。PFDA排泄减少部分解释了其相较于PFOA对大鼠毒性更大的原因。
