Tomashevskiĭ Ia I, Tomashevskaia A Ia, Ershova T A, Ho K S, Nesterovich M R
Probl Endokrinol (Mosk). 1989 Sep-Oct;35(5):45-7.
A pyruvate test for glucose tolerance was used during prophylactic medical examination of 47 students and 27 children without risk factors, 54 students with risk factors, 31 patients with type I diabetes mellitus and 220 construction workers in order to test a new methodological basis for the strategy of primary prevention of diabetes mellitus. The investigations showed the presence in a general population of 3-modal distribution of a variant of the capillary blood pyruvate level on the 120th min. of a GTT according to physiological glucose tolerance, potential (prediabetic) and actual (diabetic) carbohydrate metabolic derangements. A high informative value of the pyruvate test for glucose tolerance makes this method appropriate for identification of persons, genetically predisposed to the development of diabetes mellitus, for implementation of a population strategy of prevention of this disease as well as strategy of prevention of diabetes among persons with risk factors.
为了检验糖尿病一级预防策略的新方法基础，对47名无危险因素的学生和儿童、27名无危险因素的儿童、54名有危险因素的学生、31名1型糖尿病患者和220名建筑工人进行预防性体检时，采用了丙酮酸糖耐量试验。调查显示，根据生理糖耐量、潜在（糖尿病前期）和实际（糖尿病）碳水化合物代谢紊乱情况，在普通人群中，口服葡萄糖耐量试验（GTT）第120分钟时毛细血管血丙酮酸水平变体呈三模态分布。丙酮酸糖耐量试验具有较高的信息价值，使得该方法适用于识别易患糖尿病的人群，适用于实施该疾病的人群预防策略以及有危险因素人群的糖尿病预防策略。
