do Vale Hugo Felipe, Casarin Renato Corrêa Viana, Taiete Tiago, Bovi Ambrosano Gláucia Maria, Ruiz Karina Gonzales Silvério, Nociti Francisco Humberto, Sallum Enílson Antônio, Casati Márcio Zaffalon
Division of Periodontics, Amazonas State University, Av. Carvalho Leal 1777, Cachoeirinha, 69065-001, Manaus, AM, Brazil.
Division of Periodontics, Piracicaba Dental School, State University of Campinas, UNIP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil.
Clin Oral Investig. 2016 Jan;20(1):141-50. doi: 10.1007/s00784-015-1471-y. Epub 2015 Apr 16.
This study evaluated the clinical, immunological and microbiological results of full-mouth ultrasonic debridement (FMUD) with 10 % povidone iodine (PVPI) as the cooling liquid in the treatment of generalised aggressive periodontitis (GAgP).
Twenty-eight patients presenting GAgP were randomly assigned to one of the following groups for evaluation: FMUD + SS (n = 14)--single session of FMUD with 0.9 % saline solution as cooling agent and FMUD + PVPI (n = 14)--single session of FMUD with PVPI solution as cooling agent. Probing depth (PD), relative clinical attachment level (RCAL), relative position of gingival margin, plaque index (FMPI) and bleeding score (FMBS), immunological (interleukin-10 and interleukin-1β concentrations in gingival crevicular fluid) and microbiological (Aa and Pg amounts) parameters were evaluated at baseline, first, third and sixth months after treatment.
The two groups presented reduction of FMPI and FMBS and had statistically significant PD reductions, RCAL gains and gingival recession (p < 0.05). Both therapies reduced Pg levels in deep and in moderate pockets (p < 0.05). FMUD + PVPI reduced Aa levels in deep pockets. However, no inter-group differences in clinical, immunological and microbiological parameters were observed (p > 0.05).
It could be concluded that 10 % PVPI used as an irrigant solution in FMUD decreased Aa levels in deep pockets but had no additional benefits when compared with saline solution irrigation in terms of clinical, microbiological and immunological results.
The FMUD is a valid option for the treatment of GAgP, but the use of 10 % PVPI did not improve the results of the periodontal therapy.
本研究评估了以10%聚维酮碘（PVPI）作为冷却液进行全口超声清创术（FMUD）治疗广泛侵袭性牙周炎（GAgP）的临床、免疫学和微生物学效果。
28例GAgP患者被随机分为以下几组进行评估：FMUD + SS组（n = 14）——以0.9%生理盐水作为冷却剂进行单次FMUD治疗；FMUD + PVPI组（n = 14）——以PVPI溶液作为冷却剂进行单次FMUD治疗。在基线、治疗后第1、3和6个月评估探诊深度（PD）、相对临床附着水平（RCAL）、牙龈边缘相对位置、菌斑指数（FMPI）和出血评分（FMBS）、免疫学指标（龈沟液中白细胞介素-10和白细胞介素-1β浓度）以及微生物学指标（伴放线聚集杆菌和牙龈卟啉单胞菌数量）。
两组患者的FMPI和FMBS均降低，PD降低、RCAL增加和牙龈退缩具有统计学意义（p < 0.05）。两种治疗方法均降低了深袋和中袋中的牙龈卟啉单胞菌水平（p < 0.05）。FMUD + PVPI降低了深袋中的伴放线聚集杆菌水平。然而，未观察到两组在临床、免疫学和微生物学参数上的差异（p > 0.05）。
可以得出结论，在FMUD中用作冲洗液的10% PVPI可降低深袋中的伴放线聚集杆菌水平，但与生理盐水冲洗相比，在临床、微生物学和免疫学结果方面没有额外益处。
FMUD是治疗GAgP的有效选择，但使用10% PVPI并未改善牙周治疗效果。
