Liu Enyan, Duan Dingyu, Xie Xudong, Li Haolai, Li Maoxue, Ding Yi
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & State Institute of Drug/Medical Device Clinical Trial, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2025 Jun 1;43(3):362-369. doi: 10.7518/hxkq.2025.2024326.
This study aimed to evaluate the therapeutic effect of 1% povidone-iodine mouthwash combined with scaling and root planing in patients with stage Ⅰ/Ⅱ class A/B periodontitis, and to provide a basis for the clinical application of povidone-iodine mouthwash.
Seventy-five subjects were included in this trial and randomly divided into three groups. After full-mouth ultrasonic supragingival cleansing, scaling and root planing, the placebo group was treated with sodium chloride injection (NaCl group), the control group was treated with compound chlorhexidine mouthwash (CHX group), and the experimental group was treated with 1% povidone-iodine mouthwash (PVP-I group), and rinsed their mouths for 1 week, respectively. Subjects were tested at 1, 4, and 12 weeks after dosing for clinical indicators, microbial composition of supragingival plaque, gingival crevicular fluid inflammatory marker levels, and patient-reported outcomes.
Sixty-three subjects completed the follow-up. After treatment, the clinical indicators, microbial indicators, and inflammatory indicators were all significantly improved (<0.05). Comparisons among the groups showed that one week after treatment, the bleeding index and plaque index of the CHX group and the PVP-I group were lower than those of the NaCl group, and the plaque index of the CHX group was lower than that of the PVP-I group (<0.05). There were no statistically significant differences in the other clinical indicators among the groups (>0.05). Twelve weeks after treatment, the Shannon index of the CHX group was lower than that of the NaCl group (<0.05), and there were no statistically significant differences in the other microbial indicators among the groups (>0.05). Twelve weeks after treatment, the interleukin-10 concentration of the CHX group was higher than that of the NaCl group (<0.05), and there were no statistically significant differences in the other inflammatory indicators among the groups (>0.05). The PVP-I group had the highest scores in terms of taste and oral odor. There was no obvious staining on the tooth surfaces and mucosa in all three groups.
1% PVP-I mouthwash combined with scaling and root planing can effectively reduce gingival inflammation and dental plaque, improve clinical symptoms in the short term. While its efficacy is not significantly inferior to that of chlorhexidine, PVP-I mouthwash is more acceptable to patients than chlorhexidine.
本研究旨在评估1%聚维酮碘含漱液联合龈上洁治术和根面平整术治疗Ⅰ/Ⅱ期A/B级牙周炎患者的疗效，为聚维酮碘含漱液的临床应用提供依据。
本试验纳入75名受试者，随机分为三组。在进行全口超声龈上洁治、龈下刮治和根面平整后，安慰剂组用氯化钠注射液治疗（NaCl组），对照组用复方氯己定含漱液治疗（CHX组），试验组用1%聚维酮碘含漱液治疗（PVP-I组），分别漱口1周。在给药后1、4和12周对受试者进行临床指标、龈上菌斑微生物组成、龈沟液炎症标志物水平及患者报告结局的检测。
63名受试者完成随访。治疗后，临床指标、微生物指标和炎症指标均显著改善（<0.05）。组间比较显示，治疗1周后，CHX组和PVP-I组的出血指数和菌斑指数低于NaCl组，且CHX组的菌斑指数低于PVP-I组（<0.05）。其他临床指标在组间无统计学差异（>0.05）。治疗12周后，CHX组的香农指数低于NaCl组（<0.05），其他微生物指标在组间无统计学差异（>0.05）。治疗12周后，CHX组的白细胞介素-10浓度高于NaCl组（<0.05），其他炎症指标在组间无统计学差异（>0.05）。PVP-I组在味道和口气方面得分最高。三组牙齿表面和黏膜均无明显染色。
1%聚维酮碘含漱液联合龈上洁治术和根面平整术可有效减轻牙龈炎症和牙菌斑，短期内改善临床症状。虽然其疗效不比氯己定显著差，但聚维酮碘含漱液比氯己定更易被患者接受。
