Chen Haiyang, Zheng Xiaobin, Zheng Yixian
a Department of Embryology; Carnegie Institution for Science ; Baltimore , MD , USA.
Nucleus. 2015;6(3):183-6. doi: 10.1080/19491034.2015.1040212. Epub 2015 Apr 15.
Gradual loss of tissue function (or homeostasis) is a natural process of aging and is believed to cause many age-associated diseases. In human epidemiology studies, the low-grade and chronic systemic inflammation in elderly has been correlated with the development of aging related pathologies. Although it is suspected that tissue decline is related to systemic inflammation, the cause and consequence of these aging phenomena are poorly understood. By studying the Drosophila fat body and gut, we have uncovered a mechanism by which lamin-B loss in the fat body upon aging induces age-associated systemic inflammation. This chronic inflammation results in the repression of gut local immune response, which in turn leads to the over-proliferation and mis-differentiation of the intestinal stem cells, thereby resulting in gut hyperplasia. Here we discuss the implications and remaining questions in light of our published findings and new observations.
组织功能（或内稳态）的逐渐丧失是衰老的自然过程，并且被认为会引发许多与年龄相关的疾病。在人类流行病学研究中，老年人的低度慢性全身性炎症与衰老相关病理状况的发展有关。尽管人们怀疑组织衰退与全身性炎症有关，但对这些衰老现象的原因和后果却知之甚少。通过研究果蝇的脂肪体和肠道，我们发现了一种机制，衰老时脂肪体中的核纤层蛋白B缺失会引发与年龄相关的全身性炎症。这种慢性炎症会导致肠道局部免疫反应受到抑制，进而导致肠道干细胞过度增殖和分化异常，从而导致肠道增生。在此，我们根据已发表的研究结果和新的观察结果来讨论其意义及尚存的问题。
