1型和2型糖尿病对大鼠主动脉内皮依赖性舒张的影响。

The effects of type-1 and type-2 diabetes on endothelium-dependent relaxation in rat aorta.

作者信息

Altan V M, Karasu C, Ozüari A

机构信息

Department of Pharmacology, Faculty of Pharmacy, University of Ankara, Turkey.

出版信息

Pharmacol Biochem Behav. 1989 Jul;33(3):519-22. doi: 10.1016/0091-3057(89)90379-1.

DOI:10.1016/0091-3057(89)90379-1

PMID:2587591

Abstract

Diabetes mellitus is known to produce alterations in vascular reactivity. In the present study we have examined the effects of endothelium-dependent and endothelium-independent relaxing substances on thoracic aorta from insulin-dependent (Type-1) and noninsulin-dependent (Type-2) diabetic rats and their appropriate controls. Endothelium-dependent relaxations produced by acetylcholine and histamine in aortic rings precontracted with noradrenaline were significantly increased in insulin-dependent diabetic vessels. In contrast, the relaxations elicited by those agents were significantly attenuated in noninsulin-dependent diabetic aorta preparations. On the other hand, the relaxations induced by sodium nitroprusside (an endothelium-independent relaxant agent) in both types of diabetic preparations were comparable to those in control vessels. The results indicate that insulin-dependent and noninsulin-dependent diabetes lead to specific alterations of the endothelium-dependent relaxation of rat aorta.

摘要

众所周知，糖尿病会引起血管反应性改变。在本研究中，我们检测了内皮依赖性和非内皮依赖性舒张物质对胰岛素依赖型（1型）和非胰岛素依赖型（2型）糖尿病大鼠及其相应对照大鼠胸主动脉的影响。在去甲肾上腺素预收缩的主动脉环中，乙酰胆碱和组胺引起的内皮依赖性舒张在胰岛素依赖型糖尿病血管中显著增强。相比之下，在非胰岛素依赖型糖尿病主动脉制剂中，这些药物引起的舒张作用显著减弱。另一方面，硝普钠（一种非内皮依赖性舒张剂）在两种糖尿病制剂中引起的舒张作用与对照血管中的相当。结果表明，胰岛素依赖型和非胰岛素依赖型糖尿病会导致大鼠主动脉内皮依赖性舒张的特异性改变。