自发性糖尿病大鼠主动脉中内皮依赖性舒张功能受损。
Impairment of endothelium-dependent relaxation in aortae from spontaneously diabetic rats.
作者信息
Durante W, Sen A K, Sunahara F A
机构信息
Department of Pharmacology, University of Toronto, Ontario, Canada.
出版信息
Br J Pharmacol. 1988 Jun;94(2):463-8. doi: 10.1111/j.1476-5381.1988.tb11548.x.
Abstract
- Diabetes mellitus is known to produce alterations in vascular reactivity. The present study examined the effects of endothelium-dependent and endothelium-independent relaxing substances on thoracic aorta from control and spontaneously diabetic rats. 2. Endothelium-dependent relaxation produced by acetylcholine or the calcium ionophore, A23187, in aortic rings precontracted with phenylephrine was significantly attenuated in diabetic vessels. 3. Relaxations produced by sodium nitroprusside or adenosine in diabetic preparations were comparable to those in control vessels. 4. The results show that diabetes leads to a specific impairment of endothelial-dependent relaxation.
摘要
- 已知糖尿病会引起血管反应性改变。本研究检测了内皮依赖性和非内皮依赖性舒张物质对正常大鼠和自发性糖尿病大鼠胸主动脉的影响。2. 在用去氧肾上腺素预收缩的主动脉环中，乙酰胆碱或钙离子载体A23187所产生的内皮依赖性舒张在糖尿病血管中显著减弱。3. 糖尿病制剂中硝普钠或腺苷所产生的舒张与对照血管中的相当。4. 结果表明，糖尿病导致内皮依赖性舒张出现特异性损伤。
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