Knowles P A, Conner R L, Panksepp J
Department of Psychology, Bowling Green State University, OH 43403.
Pharmacol Biochem Behav. 1989 Jul;33(3):533-7. doi: 10.1016/0091-3057(89)90382-1.
The relationship between opioids and social behavior was examined by administering morphine (an opioid agonist) and naloxone (an opioid antagonist) to juvenile dogs and measuring various social behaviors (e.g., tail wagging) in a large room. Drugs were administered following social deprivation and nondeprivation. It was hypothesized that morphine would ease effects of social deprivation while naloxone would result in behavior typical of untreated socially-deprived dogs. Social deprivation (24 hr) resulted in more contact with the experimenter and increased tail wagging relative to nondeprivation. Morphine (0.25 mg/kg) resulted in more contacts with the experimenter and entrances into the "experimenter's area" relative to vehicle injections. Further, morphine decreased and naloxone increased tail wagging in the dog's area and there was a significant social condition X drug interaction for that measure. Naloxone (0.25 mg/kg) increased wagging following nondeprivation while morphine decreased wagging following deprivation. These data support the hypotheses that social deprivation can increase social behaviors, and that social behavior is regulated by activity in brain opioid systems.
通过给幼犬注射吗啡（一种阿片类激动剂）和纳洛酮（一种阿片类拮抗剂），并在一个大房间里测量各种社交行为（如摇尾巴），研究了阿片类药物与社交行为之间的关系。药物在社交剥夺和非剥夺后给药。据推测，吗啡会减轻社交剥夺的影响，而纳洛酮会导致未治疗的社交剥夺犬的典型行为。与非剥夺相比，社交剥夺（24小时）导致与实验者的接触更多，摇尾巴增加。与注射赋形剂相比，吗啡（0.25mg/kg）导致与实验者的接触更多，进入“实验者区域”的次数更多。此外，吗啡减少了犬所在区域的摇尾巴次数，而纳洛酮增加了该区域的摇尾巴次数，并且该测量存在显著的社交条件X药物相互作用。纳洛酮（0.25mg/kg）在非剥夺后增加了摇尾巴次数，而吗啡在剥夺后减少了摇尾巴次数。这些数据支持以下假设：社交剥夺会增加社交行为，并且社交行为受脑内阿片系统活动的调节。
