Jalowiec J E, Calcagnetti D J, Fanselow M S
Department of Psychology, Dartmouth College, Hanover, NH 03755.
Pharmacol Biochem Behav. 1989 Jul;33(3):697-700. doi: 10.1016/0091-3057(89)90409-7.
Pairs of male and female rats were injected with either tertiary naltrexone (NTX) which readily crosses the blood-brain barrier, or quaternary naltrexone (QNTX) which does not, to determine the importance of central opioid systems in the elaboration of juvenile social behavior. In the first experiment, only intraperitoneal injections of NTX (1.0 mg/kg) suppressed the frequency of wrestling pins. Peripheral injections of QNTX (10.0 mg/kg) were without effect. In a second experiment, QNTX (2.0, 4.0, or 8.0 micrograms/4.0 microliters) was injected directly into the lateral ventricles. Intracerebroventricular injection of the moderate dose reliably reduced frequency of pinning while the higher dose was severely incapacitating and the low dose was without effect. The results of these two experiments confirm an important role for brain opioid systems in the control of juvenile social interaction.
将雄性和雌性大鼠配对，分别注射易透过血脑屏障的叔纳曲酮（NTX）或不能透过血脑屏障的季纳曲酮（QNTX），以确定中枢阿片系统在幼年期社会行为形成中的重要性。在第一个实验中，仅腹腔注射NTX（1.0毫克/千克）会抑制扭打频率。外周注射QNTX（10.0毫克/千克）则无效果。在第二个实验中，将QNTX（2.0、4.0或8.0微克/4.0微升）直接注射到侧脑室。脑室内注射中等剂量可可靠地降低压制频率，而高剂量会严重致残，低剂量则无效果。这两个实验的结果证实了脑阿片系统在控制幼年期社会互动中起重要作用。
