Cooper S J
School of Psychology, University of Birmingham, U.K.
Pharmacol Biochem Behav. 1989 Jul;33(3):721-4. doi: 10.1016/0091-3057(89)90415-2.
Nondeprived, male Syrian hamsters (Mesocricetus auratus) were adapted to a daily schedule of 2-hr access to a 10% sucrose solution. Two benzodiazepines, midazolam (1.0-10 mg/kg) and flurazepam (1.0-10 mg/kg), produced dose-dependent increases in sucrose consumption. In contrast, the alpha 2-adrenergic agonist, clonidine (0.01-0.3 mg/kg), had no effect on sucrose intake. Neither d-fenfluramine nor d-amphetamine affected sucrose ingestion in the hamsters, except at a large dose (10 mg/kg). Nevertheless, significant, dose-dependent reductions in sucrose consumption were observed after the administration of either opiate antagonists (naltrexone; nalmefene) or selective dopamine D2 receptor agonists (N-0437; quinpirole). The results are compared and contrasted with previously reported data for rats.
未被剥夺食物的雄性叙利亚仓鼠（金仓鼠）适应了每天有2小时可获取10%蔗糖溶液的时间表。两种苯二氮䓬类药物，咪达唑仑（1.0 - 10毫克/千克）和氟西泮（1.0 - 10毫克/千克），使蔗糖消耗量呈剂量依赖性增加。相比之下，α2 - 肾上腺素能激动剂可乐定（0.01 - 0.3毫克/千克）对蔗糖摄入量没有影响。除了大剂量（10毫克/千克）时，右芬氟拉明和右旋苯丙胺均未影响仓鼠的蔗糖摄取。然而，给予阿片类拮抗剂（纳曲酮；纳美芬）或选择性多巴胺D2受体激动剂（N - 0437；喹吡罗）后，观察到蔗糖消耗量显著且呈剂量依赖性降低。将这些结果与先前报道的大鼠数据进行了比较和对比。
