Katz N L, Brne T, Bolin J, Schlemmer R F
Pharmacol Biochem Behav. 1986 Nov;25(5):1107-9. doi: 10.1016/0091-3057(86)90093-6.
Previous studies support an interaction between noradrenergic and opiate systems in the control of food intake. For example, in both rats and rabbits, food intake stimulated by the noradrenergic agent clonidine is reduced by opiate antagonists. The purpose of the present study was to determine whether or not clonidine stimulated the food intake of non-food-deprived hamsters, a species which appears to lack an opiate-sensitive feeding system. Hamsters fed a chow diet did not increase their food intake when injected with clonidine in doses ranging from 0.05 to 0.25 mg/kg. Furthermore, the animals did not increase their intake of sunflower seeds, a preferred diet for hamsters.
先前的研究支持去甲肾上腺素能系统与阿片系统在食物摄入控制方面存在相互作用。例如，在大鼠和兔子中，去甲肾上腺素能药物可乐定刺激的食物摄入会被阿片拮抗剂减少。本研究的目的是确定可乐定是否会刺激非饥饿仓鼠的食物摄入，仓鼠这一物种似乎缺乏对阿片敏感的进食系统。喂食普通食物的仓鼠注射0.05至0.25毫克/千克剂量的可乐定后，其食物摄入量并未增加。此外，这些动物对仓鼠偏爱的食物向日葵籽的摄入量也没有增加。
