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强力霉素作为慢性伤口炎症的调节剂。

Doxycycline as a modulator of inflammation in chronic wounds.

作者信息

Wilcox James R, Covington D Scott, Paez Nancy

机构信息

Healogics, Inc, Jacksonville, FL; email:

Healogics, Inc, Jacksonville, FL.

出版信息

Wounds. 2012 Dec;24(12):339-49.

PMID:25876218
Abstract

Doxycycline is a semisynthetic, chemically modified tetracycline compound that is rapidly absorbed and exerts biological effects independent of its antimicrobial activity. One such effect includes the inhibition of matrix metalloproteinases. Doxycycline has a long history as a collagenase inhibitor. This article will describe its mode of action and review its effectiveness in significantly reducing inflammation and elevated levels of proinflammatory cytokines within chronic wounds. .

摘要

强力霉素是一种半合成的、经化学修饰的四环素化合物，它吸收迅速，其生物学效应独立于抗菌活性。其中一种效应包括抑制基质金属蛋白酶。强力霉素作为胶原酶抑制剂已有很长的历史。本文将描述其作用方式，并综述其在显著减轻慢性伤口炎症和促炎细胞因子水平升高方面的有效性。

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