Ma Y, Chen X, Guan S
College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
Drugs Today (Barc). 2015 Mar;51(3):197-208. doi: 10.1358/dot.2015.51.3.2295906.
Terbinafine, an orally and topically active antifungal agent, has been available for the treatment of dermatophytic infections and onychomycosis for more than a decade. In addition, oral administration has been shown to be associated with drug-drug interactions, hepatotoxicity, low concentration at the infected sites, gastrointestinal and systemic side effects and other adverse effects. Since topical drug delivery can provide higher patient compliance, allow immediate access to the infected site and reduce unwanted systemic drug exposure, an improved topical drug delivery approach with high permeability, sustained release and prolonged retainment could overcome the limitations and side effects caused by oral administration. Conventional topical formulations cannot keep the drug in the targeted sites for a long duration of time and hence a novel drug delivery that can avoid the side effects while still providing sustained efficacy in treatment should be developed. This brief review of novel formulations based on polymers and nanostructure carriers provides insight into the efficacy and topical delivery of terbinafine.
特比萘芬是一种口服和局部应用均有效的抗真菌药物，已用于治疗皮肤癣菌感染和甲癣十余年。此外，口服给药已显示出与药物相互作用、肝毒性、感染部位药物浓度低、胃肠道和全身副作用以及其他不良反应有关。由于局部给药可提高患者依从性，使药物能立即到达感染部位并减少不必要的全身药物暴露，一种具有高渗透性、缓释和长效滞留的改进局部给药方法可以克服口服给药引起的局限性和副作用。传统的局部制剂不能使药物在靶点长时间停留，因此应开发一种能避免副作用同时仍能在治疗中提供持续疗效的新型给药方式。这篇基于聚合物和纳米结构载体的新型制剂的简要综述，深入探讨了特比萘芬的疗效和局部给药情况。
