Gill Jeewanjit, Pratt Melanie
University of Ottawa, Ottawa, ON, Canada
The Ottawa Hospital, Ottawa, ON, Canada.
J Cutan Med Surg. 2015 Sep-Oct;19(5):494-7. doi: 10.1177/1203475415581737. Epub 2015 Apr 15.
Pompholyx is an inflammatory vesiculobullous skin disease of the hands and feet belonging to the spectrum of eczema.
To report a severe case of pompholyx, its clinical presentation, and its management.
A medical chart review was conducted on a patient with this condition.
The patient was patch tested according to the North American Contact Dermatitis Group (NACDG) Standard Screening Series, and results were negative. In the past, she was treated with corticosteroid creams as well as narrow band ultraviolet B (UVB), and Psoralen ultraviolet A (PUVA) therapies, and none were beneficial. When the frequency of the episodes increased, methotrexate was introduced but failed to control the condition. Next, mycophenolate mofetil was started and gradually increased to 3.5 g daily along with a separate trial of radiotherapy with marked success.
Pompholyx can be challenging to manage, and treatment can involve an assortment of therapies over a prolonged period of time.
汗疱疹是一种发生于手足的炎症性水疱大疱性皮肤病，属于湿疹范畴。
报告一例严重汗疱疹病例、其临床表现及治疗情况。
对一名患有此病的患者进行病历回顾。
该患者按照北美接触性皮炎组（NACDG）标准筛查系列进行斑贴试验，结果为阴性。过去，她接受过皮质类固醇乳膏、窄谱中波紫外线（UVB）以及补骨脂素长波紫外线（PUVA）治疗，但均无效果。当发作频率增加时，开始使用甲氨蝶呤，但未能控制病情。接下来，开始使用霉酚酸酯并逐渐增加至每日3.5克，同时单独进行放疗试验，取得了显著成功。
汗疱疹的治疗可能具有挑战性，治疗可能需要在较长时间内采用多种疗法。
