Stetefeld H R, Dohmen C
Abteilung für Neurologie, Universitätsklinikum Köln, Kerpener Str. 62, 50924, Köln, Deutschland.
Med Klin Intensivmed Notfmed. 2016 Apr;111(3):215-23. doi: 10.1007/s00063-015-0021-3. Epub 2015 Apr 16.
Bacterial meningitis is a life-threatening emergency that is still associated with high mortality and poor outcome.
The purpose of this article is to provide a review of clinical presentation, diagnostic procedure, therapy, and prognosis in bacterial meningitis. Prognostic factors which could be influenced positively are identified and a focused procedure in the emergency setting and for the treatment of complications are provided.
This work is based on a literature search (PubMed, guidelines) and personal experience (standard operating procedures, SOP).
Despite improved health care, bacterial meningitis is still associated with high mortality and poor neurological outcome, which has remained largely unaltered during recent decades. Diagnosis and, more importantly, effective therapy of bacterial meningitis are often delayed, having an immediate negative influence on clinical outcome. Neurological and nonneurological complications often necessitate intensive care and may occur rapidly or in the further course of the disease.
Immediate initiation of effective therapy is crucial to positively influence mortality and neurological outcome. Antibiotics should be administered within 30 min after admission. To achieve this, a focused and well-organized procedure in the emergency setting is necessary. Because of intra- and extracranial complications, patients need to be treated on intensive care units including neurological expertise and interdisciplinary support.
细菌性脑膜炎是一种危及生命的急症,目前仍与高死亡率和不良预后相关。
本文旨在综述细菌性脑膜炎的临床表现、诊断方法、治疗及预后。确定可能产生积极影响的预后因素,并提供在急诊环境中以及治疗并发症时的重点流程。
本研究基于文献检索(PubMed、指南)及个人经验(标准操作流程,SOP)。
尽管医疗保健有所改善,但细菌性脑膜炎仍与高死亡率和不良神经学预后相关,近几十年来基本未变。细菌性脑膜炎的诊断,更重要的是有效治疗,常常延迟,对临床结果立即产生负面影响。神经学和非神经学并发症常需要重症监护,可能在疾病过程中迅速出现或在后续阶段发生。
立即开始有效治疗对于积极影响死亡率和神经学预后至关重要。抗生素应在入院后30分钟内使用。要做到这一点,在急诊环境中需要一个重点突出且组织有序的流程。由于颅内和颅外并发症,患者需要在具备神经学专业知识和多学科支持的重症监护病房接受治疗。