Zhang Chao, Zhou Xia, Wang Long, Liu Han, Zhu Minmin, Sun Zhongwu
Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China.
Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China. Email:
Zhonghua Yi Xue Za Zhi. 2015 Jan 6;95(1):44-7.
To explore the relationship between the degree of vascular stenosis and cognition in leukoaraiosis patients.
A total of 101 leukoaraiosis patients from the Department of Neurology, The First Affiliated Hospital of Anhui Medical University between September 2013 and June 2014, divided into two groups:patients with cognitive impairment (SVCI) (n = 54) , and those without cognitive impairment (NC) (n = 47) . All patients were enrolled and examined by magnetic resonance imaging (MRI) scanning and magnetic resonance angiography (MRA) or computed tomography angiography (CTA). The cognitive assessments were made by MMSE (mini-mental state examination), CAMCOG-C (Cambridge cognitive examination-Chinese version) and CDR (clinical dementia rating). The severity of leukoaraiosis and vascular stenosis was graded by MRI and MRA/CTA scans.
The degree of vascular stenosis group and the severity of LA in SVCI were significantly higher than NC (2.0 ± 0.8 vs1.1 ± 0.6, 2.6 ± 1.0 vs 2.0 ± 1.0; P = 0.020, P = 0.003). As white matter level aggravated, cognitive function decreased and vascular stenosis deteriorated accordingly, and the score of MMSE (25 ± 4, 24 ± 6, 22 ± 4) and CAMCOG-C (83 ± 14, 80 ± 14, 73 ± 14) has a statistical significance (P = 0.012, P = 0.014). At the same time, the negative correlation was found in LA patients between cognitive function and severity of LA (r = -0.317, P = 0.001) as well as degree of vascular stenosis (r = -0.284, P = 0.004). Multivariate Logistic regression analysis revealed that, after controlling for various factors, both severity of LA (OR = 2.025, 95% CI 1.307-3.954) and the degree of vascular stenosis (OR = 1.812, 95% CI 1.129-2.908) were risk factors for cognitive impairment in leukoaraiosis patients.
Cognition of leukoaraiosis patients is correlated with both severity of leukoaraiosis and vascular stenosis.
探讨脑白质疏松症患者血管狭窄程度与认知功能之间的关系。
选取2013年9月至2014年6月安徽医科大学第一附属医院神经内科的101例脑白质疏松症患者，分为两组：认知功能障碍（SVCI）患者（n = 54）和无认知功能障碍（NC）患者（n = 47）。所有患者均接受磁共振成像（MRI）扫描及磁共振血管造影（MRA）或计算机断层血管造影（CTA）检查。采用简易精神状态检查表（MMSE）、剑桥认知检查表中文版（CAMCOG-C）和临床痴呆评定量表（CDR）进行认知功能评估。通过MRI和MRA/CTA扫描对脑白质疏松症和血管狭窄的严重程度进行分级。
SVCI组的血管狭窄程度及脑白质疏松症严重程度均显著高于NC组（2.0±0.8对1.1±0.6，2.6±1.0对2.0±1.0；P = 0.020，P = 0.003）。随着脑白质水平加重，认知功能下降，血管狭窄也相应恶化，MMSE评分（25±4，24±6，22±4）和CAMCOG-C评分（83±14，80±14，73±14）具有统计学意义（P = 0.012，P = 0.014）。同时，脑白质疏松症患者的认知功能与脑白质疏松症严重程度（r = -0.317，P = 0.001）以及血管狭窄程度（r = -0.284，P = 0.004）呈负相关。多因素Logistic回归分析显示，在控制各种因素后，脑白质疏松症严重程度（OR = 2.025，95%CI 1.307 - 3.954）和血管狭窄程度（OR = 1.812，95%CI 1.129 - 2.908）均为脑白质疏松症患者认知功能障碍的危险因素。
脑白质疏松症患者的认知功能与脑白质疏松症严重程度及血管狭窄程度均相关。
