Kleinert G
Radiobiol Radiother (Berl). 1989;30(5):473-80.
Prognostically relevant factors as well as indications for percutaneous radiotherapy are analysed by the hand of a retrospective analysis of therapeutic results in 86 patients that were exposed a percutaneous radiotherapy because of a thyroid carcinoma at the Clinic and Policlinic of the Medical Academy Erfurt during the period 1972 to 1982. The 5-years-survivals of 83% for patients with differentiated carcinoma and 22% for patients with dedifferentiated carcinoma prove the influence of tumor histology on prognosis of the disease. Next to it the locoregional tumor spreading at beginning of therapy rendered prognostically relevant. The 5-years-survival was 83% in tumor stages T1-3N0M0. With metastatic infiltration into lymph-nodes of the neck the 5-years-survival decreased to 57%, with spreading of the primary tumor beyond organ borders to 23.5%. The postoperative percutaneous radiotherapy should be applied in all cases of metastatic infiltration of lymph-nodes. In large, inoperable tumors the percutaneous radiotherapy is the solely possible palliative measure that should be applied both in differentiated and also in anaplastic carcinomas in spite of infaust prognosis.
通过对1972年至1982年间在爱尔福特医学院临床与门诊因甲状腺癌接受经皮放疗的86例患者的治疗结果进行回顾性分析，分析了预后相关因素以及经皮放疗的指征。分化型癌患者的5年生存率为83%，未分化型癌患者为22%，这证明了肿瘤组织学对疾病预后的影响。除此之外，治疗开始时的局部区域肿瘤扩散具有预后相关性。肿瘤分期为T1-3N0M0的患者5年生存率为83%。颈部淋巴结发生转移浸润时，5年生存率降至57%，原发肿瘤扩散至器官边界以外时为23.5%。所有淋巴结发生转移浸润的病例均应进行术后经皮放疗。对于体积较大、无法手术的肿瘤，经皮放疗是唯一可行的姑息性措施，无论预后如何，分化型癌和间变性癌均应采用。
