Zhou Luwei, Xu Manfei, Wu Zhisheng, Shi Xinyuan, Qiao Yanjiang
Beijing University of Chinese Medicine, China, 100102.
Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine (TCM) of Ministry of Education, China, 100102.
Drug Test Anal. 2016 Jan;8(1):71-85. doi: 10.1002/dta.1799. Epub 2015 Apr 15.
Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.
近红外化学成像（NIR-CI）是一种将传统近红外光谱与化学成像相结合的新兴技术。因此，NIR-CI可以从药品中提取光谱信息，同时可视化化学成分的空间分布。NIR-CI的快速和非破坏性特点使其成为制药生产过程中识别和监测关键控制参数的一种有吸引力的过程分析技术（PAT）。本综述主要关注NIR-CI在从西方固体剂型到中药制剂的生产过程中各单元操作的制药应用。最后，讨论了化学成像在制药行业的未来应用。
